Due to the long time spans, the first plague pandemic (6th century – 8th century) and the second plague pandemic (14th century – early 19th century) are shown by individual outbreaks, such as the Plague of Justinian (first pandemic) and the Black Death (second pandemic). An epidemic is the rapid spread of disease to a large number of people in a given population within a short period of time in meningococcal infections, an attack rate in excess of 15 cases per 100,000 people for two consecutive weeks is considered an epidemic. Widespread non-communicable diseases such as cardiovascular disease and cancer are not included. This is a list of the largest known epidemics and pandemics caused by an infectious disease. A plague epidemic raged in Augsburg, Bavaria, between 16. Panels of this kind were placed on the walls of houses to warn against the plague. 17th-century German "plague panel" depicting the triumph of death.
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